Treatment Targeting PI3K May Delay Resistance to Anti-HER2 Therapy in Breast...
* Early use of PI3K inhibitors may prevent or delay treatment resistance. * Cancer cells resistant to anti-HER2 therapy had high levels of survivin. * Newly identified biomarker may help predict...
View ArticleCommon Genetic Alteration Found in Head and Neck Cancers May Not be Key to...
* Common pathway activation may not be "driving" tumor. * Deregulation of several genetic pathways may explain treatment resistance.
View ArticleMicroRNA Molecule May Serve as Biomarker, Target for Brain Metastases in...
* MicroRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells. * miR-7 attenuated cancer stem-like cells' capacity for brain metastasis in mice. * MicroRNA molecule suppressed...
View ArticleAmerican Association for Cancer Research Hosts AACR Annual Meeting 2013
Foremost international meeting highlights breakthroughs in cancer research Washington, D. C. , April 6-10, 2013.
View ArticleAACR Hosts Congressional Briefing on Cancer Progress, NIH Funding
* Briefing contained updated data on economic impact of NIH funding. * Research leaders and patients addressed cancer progress. * High-resolution photos available to the media.
View ArticleNew Drug Combination Could Prevent Head and Neck Cancer in High-Risk Patients
* Preclinical combination of an EGFR inhibitor and a COX-2 inhibitor was effective. * Advanced oral precancerous lesions were eliminated in three patients. * Drug combination could be a new strategy to...
View ArticleBiomarker May Identify Neuroblastomas With Sensitivity to BET Bromodomain...
* MYCN gene is commonly amplified in neuroblastoma and associated with poor prognosis. * A BET bromodomain inhibitor downregulated MYCN expression. * The drug prolonged survival in three animal models...
View ArticleObesity, Physical Inactivity Linked with Risk for Certain Molecular Subtype...
* Obesity increased risk; physical activity lowered risk. * Data consistent with prior research linking exercise to decreased mortality. * Research on colon cancer should incorporate heterogeneity of...
View ArticleVisceral Fat Causally Linked to Intestinal Cancer
* Loss of fat by surgical removal or a calorie-restricted diet reduced likelihood of developing intestinal tumors. * Differences were found between male and female mice. * Study emphasizes the need for...
View ArticleNewly Identified Biomarkers May Help Predict Progression of Barrett's...
* Expression of most microRNAs was similar between the two conditions. * A small number were differentially expressed. * These microRNAs could be biomarkers for early diagnosis of progression.
View ArticleAACR Announces Annual Meeting Press Conference Schedule
* Press conferences will highlight key scientific breakthroughs. * Full press releases will be distributed, under embargo, on April 1. * Reporters who cannot attend in person can call in: 1 (800)...
View ArticleTrio of Biomarkers May Help Identify Kidney Cancer in Early Stages
* Biomarkers could help catch otherwise hard-to-detect cancer. * Three-marker assay has high sensitivity and specificity. * Researchers are seeking FDA approval.
View ArticleGene Profile May Help Identify Risk for Hormone-Sensitive,...
* Levels of 13 genes elevated in unaffected breasts of women with hormone receptor-negative breast cancer. * Eight of the genes were associated with lipid metabolism. * Ability to identify those at...
View ArticleFunctional Characteristics of Antitumor T Cells Change With Increasing Time...
* Beneficial effect of genetically engineered antitumor T cells was transient. * Functionality of T cells changed over time. * Strategies are needed to sustain antitumor functionality.
View ArticleEarly-Onset Baldness in African-American Men May Be Linked to Prostate Cancer
* African-American men are at high risk for developing prostate cancer. * Bald African-American men younger than 60 years of age were at greatest risk. * Frontal balding increased risk of severe disease.
View ArticleGanetespib Demonstrates Potency Against ALK-Positive Lung Cancer and...
* Ganetespib killed ALK-driven NSCLC cell lines more effectively than crizotinib. * Displayed greater antitumor activity and prolonged survival in a mouse model. * Potential as a new option for...
View ArticleNumber of Cancer Survivors Expected to Increase to 18 Million by 2022
* The current number of cancer survivors is 13.7 million. * The increase is primarily due to aging of the population. * Survival is not uniform across cancer types.
View ArticleNew Metabolite-Based Diagnostic Test Could Help Detect Pancreatic Cancer Early
* Test requires measurement of certain metabolite levels in patients' blood. * Diagnostic test showed high sensitivity and specificity.
View ArticleAmerican Association for Cancer Research to Host Annual Meeting 2013
The American Association for Cancer Research will host the AACR Annual Meeting 2013 from April 6-10 at the Walter E. Washington Convention Center in Washington, D.C.
View ArticleCisplatin-Resistant Cancer Cells Sensitive to Experimental Anticancer Drugs...
* Cisplatin-resistant non-small cell lung cancer cells expressed high levels of hyperactivated PARP1. * Cells succumbed to PARP inhibitors in vitro. * PARP inhibitor slowed cisplatin-resistant tumor...
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