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Treatment Targeting PI3K May Delay Resistance to Anti-HER2 Therapy in Breast...

* Early use of PI3K inhibitors may prevent or delay treatment resistance. * Cancer cells resistant to anti-HER2 therapy had high levels of survivin. * Newly identified biomarker may help predict...

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Common Genetic Alteration Found in Head and Neck Cancers May Not be Key to...

* Common pathway activation may not be "driving" tumor. * Deregulation of several genetic pathways may explain treatment resistance.

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MicroRNA Molecule May Serve as Biomarker, Target for Brain Metastases in...

* MicroRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells. * miR-7 attenuated cancer stem-like cells' capacity for brain metastasis in mice. * MicroRNA molecule suppressed...

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American Association for Cancer Research Hosts AACR Annual Meeting 2013

Foremost international meeting highlights breakthroughs in cancer research Washington, D. C. , April 6-10, 2013.

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AACR Hosts Congressional Briefing on Cancer Progress, NIH Funding

* Briefing contained updated data on economic impact of NIH funding. * Research leaders and patients addressed cancer progress. * High-resolution photos available to the media.

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New Drug Combination Could Prevent Head and Neck Cancer in High-Risk Patients

* Preclinical combination of an EGFR inhibitor and a COX-2 inhibitor was effective. * Advanced oral precancerous lesions were eliminated in three patients. * Drug combination could be a new strategy to...

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Biomarker May Identify Neuroblastomas With Sensitivity to BET Bromodomain...

* MYCN gene is commonly amplified in neuroblastoma and associated with poor prognosis. * A BET bromodomain inhibitor downregulated MYCN expression. * The drug prolonged survival in three animal models...

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Obesity, Physical Inactivity Linked with Risk for Certain Molecular Subtype...

* Obesity increased risk; physical activity lowered risk. * Data consistent with prior research linking exercise to decreased mortality. * Research on colon cancer should incorporate heterogeneity of...

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Visceral Fat Causally Linked to Intestinal Cancer

* Loss of fat by surgical removal or a calorie-restricted diet reduced likelihood of developing intestinal tumors. * Differences were found between male and female mice. * Study emphasizes the need for...

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Newly Identified Biomarkers May Help Predict Progression of Barrett's...

* Expression of most microRNAs was similar between the two conditions. * A small number were differentially expressed. * These microRNAs could be biomarkers for early diagnosis of progression.

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AACR Announces Annual Meeting Press Conference Schedule

* Press conferences will highlight key scientific breakthroughs. * Full press releases will be distributed, under embargo, on April 1. * Reporters who cannot attend in person can call in: 1 (800)...

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Trio of Biomarkers May Help Identify Kidney Cancer in Early Stages

* Biomarkers could help catch otherwise hard-to-detect cancer. * Three-marker assay has high sensitivity and specificity. * Researchers are seeking FDA approval.

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Gene Profile May Help Identify Risk for Hormone-Sensitive,...

* Levels of 13 genes elevated in unaffected breasts of women with hormone receptor-negative breast cancer. * Eight of the genes were associated with lipid metabolism. * Ability to identify those at...

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Functional Characteristics of Antitumor T Cells Change With Increasing Time...

* Beneficial effect of genetically engineered antitumor T cells was transient. * Functionality of T cells changed over time. * Strategies are needed to sustain antitumor functionality.

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Early-Onset Baldness in African-American Men May Be Linked to Prostate Cancer

* African-American men are at high risk for developing prostate cancer. * Bald African-American men younger than 60 years of age were at greatest risk. * Frontal balding increased risk of severe disease.

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Ganetespib Demonstrates Potency Against ALK-Positive Lung Cancer and...

* Ganetespib killed ALK-driven NSCLC cell lines more effectively than crizotinib. * Displayed greater antitumor activity and prolonged survival in a mouse model. * Potential as a new option for...

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Number of Cancer Survivors Expected to Increase to 18 Million by 2022

* The current number of cancer survivors is 13.7 million. * The increase is primarily due to aging of the population. * Survival is not uniform across cancer types.

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New Metabolite-Based Diagnostic Test Could Help Detect Pancreatic Cancer Early

* Test requires measurement of certain metabolite levels in patients' blood. * Diagnostic test showed high sensitivity and specificity.

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American Association for Cancer Research to Host Annual Meeting 2013

The American Association for Cancer Research will host the AACR Annual Meeting 2013 from April 6-10 at the Walter E. Washington Convention Center in Washington, D.C.

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Cisplatin-Resistant Cancer Cells Sensitive to Experimental Anticancer Drugs...

* Cisplatin-resistant non-small cell lung cancer cells expressed high levels of hyperactivated PARP1. * Cells succumbed to PARP inhibitors in vitro. * PARP inhibitor slowed cisplatin-resistant tumor...

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